Storonova O., Poluektova E., Kuchumova S. et al. Association between SIBO, characteristics of anorectal motility and rectal sensitivity in patients with diarrhea-predominant irritable bowel syndrome // Neurogastroenterol Motil. 2017 Aug;29 Suppl 2: p.107.

Авторы: Сторонова О.А. / Полуэктова Е.А. / Кучумова С.Ю. / Ивашкин В.Т. / Шептулин А.А. / Шифрин О.С. / Ульянин А.И. / Трухманов А.С.

Association between small intestinal bacterial overgrowth, characteristics of anorectal motility and rectal sensitivity in patients with diarrhea-predominant irritable bowel syndrome

O. Storonova¹; E. Poluektova²; S. Kuchumova²; V. Ivashkin²; A. Sheptulin²; O. Shifrin²; A. Ulyanin²; A. Trukhmanov²

¹Moscow State Medical University, Russia; ²Sechenov University, Moscow, Russia

Objective: To assess correlation between small intestinal bacterial overgrowth (SIBO), anorectal motility disorders and visceral hyper-sensitivity in patients with diarrhea-predominant IBS (IBS-D).

Methods: 31 patients with IBS-D (according to the ROME III criteria) and 15 healthy volunteers were studied. All persons were analysed by the hydrogen breath test with lactulose using Gastro+Gastrolyzer (Bedfont, UK) to determine SIBO, high-resolution anorectal manometry (HRAM) using 20 channel water-perfused catheter with a polyethylene balloon (Solar GI, MMS, the Netherlands).

Results: SIBO was found in 20 patients with IBS-D (62,5%) and was not detected in the control group. A negative correlation was revealed between SIBO and the following parameters of rectal sensitivity and function of the anal sphincter (AS): average absolute anal squeeze pressure (Kendall's tau coefficient -0.34; P=.012), maximum absolute anal squeeze pressure (Kendall's tau coefficient -0.35; P=.011), threshold for intense urge to defecate (Kendall's tau coefficient -0.31; P=.022) and maximum tolerable volume (Kendall's tau coefficient -0.31; P=.025).

Conclusions: SIBO are correlated with the parameters of anorectal motility and rectal sensitivity, causing symptoms in IBS patients.

Policy of full disclosure: None.

---

Тезисы стендового доклада опубликованы в журнале: Neurogastroenterology & Motility, Special Issue: Abstract Supplement for NeuroGASTRO 2017 Congress, 24-26 August 2017, Cork, Ireland.

Дополнительная информация о конференции в публикации: Трухманов А.С., Сторонова О.А. Конгресс NeuroGastro 2017 / www.gastroscan.ru. 2017.

О.А. Сторонова и J. Tack перед стендовым докладом

Е.А. Полуэктова перед стендовым докладом

Назад в раздел