Impedance-pH reflux patterns in patients with non-erosive reflux disease
Valeria Kaibysheva*, Alexander Trukhmanov, Vladimir Ivashkin
First Moscow state medical university, Moscow, Russian Federation
Aims: To assess acid and non-acid reflux patterns in patients with non-erosive reflux disease (NERD) and erosive reflux disease (ERD) using combined esophageal pH-impedance monitoring.
Metods: 90 patients with NERD (67,6%) and 43 patients with ERD (32,3%) were underwent ambulatory 24-h esophageal pH-impedance monitoring.
Results: esophageal mucosa's exposure to reflux volume during 24 hour period was similar in both ERD and NERD patients (3.8% vs. 3.1%, p>0.05). Reflux-related acid exposure (pH drops (pH<4) associated with reflux detected by impedance) and reflux-related alkaline exposure (pH elevation (pH>7) associated with reflux detected by impedance) in ERD patients was higher than in NERD patients (p<0.05).
Fig. I. 24-h total bolus exposure in ERD and NERD patients