Rustamov M.N. Different probiotic strains improve Helicobacter pylori eradication and gut microbiota / 10 th Probiotics, Prebiotics & New Foods, Nutraceuticals and Botanicals - for Nutrition & Human and Microbiota Health. Rome, 2019. P. 137.

Авторы: Рустамов М.Н.

Different probiotic strains improve Helicobacter pylori eradication and gut microbiota

Objective

To investigate the effects of probiotics (P) in patients with Helicobacter pylori (Hp)-positive duodenal ulcer (DU).

Material and methods

In this study 200 Hp - positive patients with DU were randomized into 4 groups, 50 patients in each. Hp was confirmed histologically in samples obtained from the antrum and corpus of stomach. Intragastric and intraduodenal pH-metry by tool Gastroscan-5M, Investigation of gut microbiota, blood analyses also were performed. The following eradication regimens were recommended:

• Group I: 10-days twice daily oral administration of PPIs in standard dose, amoxicillin 1000 mg, clarithromycin 500 mg, then 20-days twice daily PPIs plus twice daily oral administration of P, containing 3,025 billion alive lyophilized Lactobacillus bulgaricus DDS-14, Lactobacillus rhamnosus, Lactobacillus acidophilus DDS-1 and Bifidobacterium bifidum during 1 month;
• Group II: PPIs and P twice daily and alkaline hydrocarbonatechloride sodium mineral water (MW) 200 ml trice daily during 1 month;
• Group III: PPIs and P twice daily and chloride sodium MW 200 ml trice daily during 1 month;
• Group IV: P and PPIs once daily during 1 month. Therapeutic success was confirmed by a negative histological examination, performed in 4-12 weeks after therapy.

Results

Before treatment, all examined patients revealed intestinal dysbiosis. In Group I dyspeptic complaints (DC) disappeared in 74%, and decreased in 20%. Disappearance of DC was 78%, 76% and 74% in II, III and IV groups respectively. Decrease of DC was 20%, 22% and 24% in II, III and IV groups respectively. The eradication rates were 82%, 80%, 78% and 68% in I, II, III and IV groups, respectively. Healing of DU was noted in 84%, 86%, 84% and 78% of cases, in I, II, III and IV groups, respectively. Intragastric and intraduodenal pH increased in all groups, especially in II. In II, III and IV groups significantly decreased alanine transaminase, asparagines transaminase, blood bilirubin, alkaline phosphatase, cholesterol and triglycerides. After treatment gut microbiota became to normal rages.

Conclusions

Adding P to standard triple therapy improves compliance and efficacy of Hp eradication. The combined use of PPIs, P and alkaline hydrocarbonatechloride sodium MW improves efficacy of Hp eradication, reduces adverse effects with antibiotics, and gut microbiota.

This regimen may especially be helpful in patients with a history of gastrointestinal adverse effects with antibiotics, comorbid patients.

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