Rustamov M.N., Lazebnik L.B. Nonpharmacologic remedies improves Helicobacter pylori eradication in patients with duodenal ulcer // Гастроэнтерология Санкт-Петербурга. - 2018. №2. С. 114-115.

Авторы: Рустамов М.Н. / Лазебник Л.Б.

Nonpharmacologic remedies improves Helicobacter pylori eradication in patients with duodenal ulcer

Rustamov M.N.¹, Lazebnik L.B.²

¹ Belamsian State Medical University, Minsk, Belams, ² Moscow State Medical University of Dentistry, Russia

Background. Current interest in probiotics is stimulated by the increasing resistance of Helicobacter pylori (HP) to antibiotics. It is also found out that mineral water has an inhibitory effect on Helicobacter pylori in vitro.

Aim: to investigate the effect of probiotics and mineral water in patients with HP-positive duodenal ulcer.

Materials and methods. 150 HP-positive duodenal ulcer patients were randomized into 3 groups. Hp was confirmed histologically and by Breath Helik-Test. pH-metry, blood analyses also were performed. Eradication included: Group I: 10-days twice daily PPIs, amoxicillin, clarithromycin, then 20-days PPIs plus once daily probiotics; Group II: PPIs, probiotics and alkaline mineral water; Group III: probiotics and PPIs. Treatment in all groups lasted for one month. Therapeutic success was confirmed in 4-12 weeks after therapy.

Results. In Group I dyspeptic complaints (DC) disappeared in 74%, and decreased in 20%. Disappearance of DC was 78%, and 74% in II and III groups respectively.
  
Eradication rates were 82%, 80% and 68% in I, II, and III groups, respectively. Healing of duodenal ulcer was in 84%, 86%, and 78% of cases, in I, II and III groups, respectively. Intragastric and intraduodenal pH was significantly increased in all groups, especially in II. After treatment in II, III and IV groups significantly decreased alanine transaminase, asparagines transaminase, blood bilirubin, alkaline phosphatase, cholesterol and triglycerides. Conclusions. Adding probiotics to standard triple therapy improves efficacy of eradication. Combined use of PPIs, probiotics and alkaline mineral water is a highly-effective alternative therapy in patients with HP-associated duodenal ulcer.

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