Storonova O., Poluektova E., Kuchumova S. et al. Association between SIBO, characteristics of anorectal motility and rectal sensitivity in patients with diarrhea-predominant irritable bowel syndrome // Neurogastroenterol Motil. 2017 Aug;29 Suppl 2: p.107.
Association between small intestinal bacterial overgrowth, characteristics of anorectal motility and rectal sensitivity in patients with diarrhea-predominant irritable bowel syndrome
O. Storonova1; E. Poluektova2; S. Kuchumova2; V. Ivashkin2; A. Sheptulin2; O. Shifrin2; A. Ulyanin2; A. Trukhmanov2
1Moscow State Medical University, Russia; 2Sechenov University, Moscow, Russia
Objective: To assess correlation between small intestinal bacterial overgrowth (SIBO), anorectal motility disorders and visceral hyper-sensitivity in patients with diarrhea-predominant IBS (IBS-D).
Methods: 31 patients with IBS-D (according to the ROME III criteria) and 15 healthy volunteers were studied. All persons were analysed by the hydrogen breath test with lactulose using Gastro+Gastrolyzer (Bedfont, UK) to determine SIBO, high-resolution anorectal manometry (HRAM) using 20 channel water-perfused catheter with a polyethylene balloon (Solar GI, MMS, the Netherlands).
Results: SIBO was found in 20 patients with IBS-D (62,5%) and was not detected in the control group. A negative correlation was revealed between SIBO and the following parameters of rectal sensitivity and function of the anal sphincter (AS): average absolute anal squeeze pressure (Kendall's tau coefficient -0.34; P=.012), maximum absolute anal squeeze pressure (Kendall's tau coefficient -0.35; P=.011), threshold for intense urge to defecate (Kendall's tau coefficient -0.31; P=.022) and maximum tolerable volume (Kendall's tau coefficient -0.31; P=.025).
Conclusions: SIBO are correlated with the parameters of anorectal motility and rectal sensitivity, causing symptoms in IBS patients.Policy of full disclosure: None.
Тезисы стендового доклада опубликованы в журнале: Neurogastroenterology & Motility, Special Issue: Abstract Supplement for NeuroGASTRO 2017 Congress, 24-26 August 2017, Cork, Ireland.
Дополнительная информация о конференции в публикации: Трухманов А.С., Сторонова О.А. Конгресс NeuroGastro 2017 / www.gastroscan.ru. 2017.
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