Prosolenko K.A., Kruchka A.V., Nemenushchaya E.I. The comparative efficacy of preparations of omeprazole in the treatment of GERD // 6th ISIC for medical students and young doctors, Kharkiv, 16-17 May 2013: Abstract book / KhNMU. Kharkiv, 2013. Р. 99-100.
The comparative efficacy of preparations of omeprazole in the treatment of GERD
K.A. Prosolenko, A.V. Kruchka, E.I. Nemenushchaya
Kharkiv National Medical University, Kharkiv, Ukraine Introduction: the prevalence of people of working age and the presence of complications of GERD can be rightfully attributed to diseases of the 21st century. PPI are the drugs of choice in the treatment of GERD. Omeprazole - are the most assigned PPI in Ukraine, so we compare the effectiveness of two drugs from the group of omeprazole.
Aim: comparative characteristics of the effectiveness and safety of drugs "Oprazol" producer company "Al-Hikma Pharmaceuticals," Jordan and "Omez" producer company "Doctor Reddis" India in patients with gastroesophageal reflux disease.
Material and methods: it was examined 20 patients (13 men and 7 women), mean age of the patients was (29,7±4,2) years. Daily pH study was performed after taking the above mentioned omeprazole - 20 mg 2 times a day for 5 days, using pH meter "Gastroskan-24”, Russia. 10 patients received Omez and 10 received Oprazol.
Evaluated the following parameters: average intragastric pH,% time pH greater than 4 (% t pH> 4), (length of time the drug), presence of nocturnal acid breakthrough (CNR).
Results: In analyzing the performance of the studied patients revealed significant differences on average intragastric pH - 5,3±0,72 in Omez vs 5,4±0,66 in Oprazol (p>0,05). Estimating rate % t pH>4, which is characterized by antisecretory effect of drugs, the figure was Omez (78,6±8,55)%, while the figure was Oprazol (74,0±6,1)% (P>0,05).
Conclusion: "Oprazol" comparable to the drug "Omez" on the efficacy and safety profiles condition.
Prosolenko K.A., Kruchka A.V., Nemenushchaya E.I. The comparative efficacy of preparations of omeprazole in the treatment of GERD // 6th International Scientific Interdisciplinary Conference (ISIC) for medical students and young doctors, Kharkiv, 16-17 May 2013 : Abstract book / KhNMU. – Kharkiv, 2013. – Р. 99-100.
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