Kosenko P.M., Vavrinchuk S.A. Electrogastroenterography in patients with complicated peptic ulcer disease / Yelm, WA, USA: Science Book Publishing House, 2013. 142 p.


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Electrogastroenterography in patients with complicated peptic ulcer disease

P.M. Kosenko,S.A.Vavrinchuk


Electrogastrography in patients with complicated peptic ulcer diseaseThe monograph is dedicated to one of most actual issues of functional surgery of ulcer disease – pre- and post-operational diagnostics and prevention of motor-evacuator disorders of stomach and intestine. The monograph contains electrophysiological characteristics of motor-evacuator gastrointestinal disorders in patients with complicated ulcer disease.

For the first time for analysis of peripheral electrogastroeneterography data we used the multivariate statistical analysis, which allowed us to determine age and gender specifics of gastrointestinal motorics and create electrophysiological models of motor-evacuator gastrointestinal disorders.

Separately we reviewed the issue of choice of surgical methods of treatment of complicated ulcer disease, specifics of gastric motorics in patients with ulcerative pyloroduodenal stenosis after different surgical interventions and correction of post-operational motor-evacuator disorders.

The monograph is for surgeons and gastroenterologists.



ISBN 978-1-62174-026-1

©Kosenko P.M., Vavrinchuk S.A.

TABLE OF CONTENTS

List of abbreviations

Introduction

Chapter 1.Modern state of issue of motor and evacuator gastric and duodenal disorders in patients with complicated ulcer disease
1.1 Main causes of gastric and duodenal MEF disorders in patients with complicated ulcer disease
1.2 Post-operational gastric and duodenal MEF disorders
1.3 Development of special methods for diagnostics of gastric and duodenal MEF disorders in patients with ulcer
1.4 Electrophysiological methods of gastric and duodenal MEF diagnostics

Chapter 2.Characteristics of clinical observation and methods of study
2.1General characteristics of clinical observations
2.2Scope and method of study
2.3Methods of statistical analysis

Chapter 3.PEGEG parameters of studied control group, age and gender specific of gastrointestinal motor function
3.1Evaluation of electrophysiological gastrointestinal state and correlation connections of PEGEG parameters
3.2Age and gender specifics of PEGEG parameters
3.3Factor analysis of PEGEG parameters

Chapter 4.Electrophysiological characteristics of gastrointestinal MEF in patients with ulcer disease complicated by bleeding
4.1Clinical characteristics of patients
4.2Analysis of PEGEG parameters in patients with duodenal ulcer complicated by bleeding
4.3Analysis of PEGEG parameters in patients with gastric ulcer complicated by bleeding
4.4Comparison of PEGEG parameters with consideration of age specifics
4.5Modeling of gastrointestinal MEF in patients with ulcer disease complicated by bleeding

Chapter 5.Electrophysiological characteristics of gastrointestinalMEF in patients with ulcer disease complicated by pylo-roduodenal stenosis
5.1Clinical characteristics of patients
5.2Methodological particularities of PEGEG parameters in patients with ulcerative PDS
5.3Analysis of PEGEG parameters in patients with compensated PDS
5.4Cluster analysis of PEGEG parameters
5.5Electrophysiological characteristics of gastrointestinal MEF in patients with hypo- and hypermotor types of subcompensated PDS
5.6Analysis of PEGEG parameters in patients with ulcer complicated by subcompensated PDS
5.7Determination of compensation degree of ulcer PDS on the basis of PEGEG parameters

Chapter 6.Electrophysiological characteristics of gastrointestinal MEF after radical duodenoplasty combined with selective proximal vagotomy
6.1Analysis of PEGEG parameters after RDP in combination with SPV in patients with subcompensated PDS of hypermotor type
6.2Analysis of PEGEG parameters after RDP in combination with SPV in patients with subcompensated PDS of hypomotor type
6.3Analysis of PEGEG parameters after RDP in combination with SPV in patients with decompensated PDS after surgical treatment
6.4Analysis of PEGEG parameters after gastric resection in patients with decompensated PDS

Chapter 7.Electrophysiological characteristics of gastrointestinal MEF in patients with duodenal ulcer disease complicated by perforation
7.1Clinical characteristics of patients
7.2Analysis of PEGEG parameters after sealing of perforated duodenal ulcer
7.3Analysis of PEGEG parameters in patients with perforated duodenal ulcer after RDP
7.4Modeling of gastrointestinal MEF in patients with perforated duodenal ulcer after sealing of perforated ulcer and RDP

Literature

ABBREVIATIONS LIST

BEM - basal electrical rhythm

GEA - gastroenteroanastomosis

GER - gastroesophageal reflux

GERD - gastroesophageal reflux disease

GIT - gastro-intestinal tract

SW - slow waves

MMK - migrating motor complex

MVSA - multivariate statistical analysis

MEF - motor-evacuation function

AIO - acute intestinal obstruction

PDS - pyloroduodenal stenosis

PEGEG - peripheral electrogastroenterography

PU - perforated ulcer

RDP-radical duodenoplasty

TV-truncal vagotomy

SGV-selective gastric vagotomy

SPV- selective proximal vagotomy

CDDP-chronic disorder of duodenal patency

EA - electrical activity

EMG electromyography

EGG electrogastrography

EGEG electrogastroenterography

IC - image converter

UD ulcer disease

FGDS fibrogastroduodenoscopy

INTRODUCTION

Gastric and duodenal ulcer remains the widespread disease that is present in up to 10-15% of working population of developed countries and takes one of the first places in the structure of gastrointestinal diseases, and the number of its complicated forms shows no tendency for decrease [69, 103, 121, 132, 146]. Disorders of gastric and duodenal MEF are present in 10.0-56.3% of patients with ulcer [2, 35, 38, 93, 121] and in up to 65% cases after its surgical treatment [14, 34, 41, 89,160], which makes the issue of timely diagnostics and prevention of post-operational MEF disorders no less actual.

The issue of adequate determination of gastric motor function in all the patients’ treatment stage remains the "milestone" of functional ulcer surgery, on solution of which depends the choice of optimal method of surgical treatment, prevention of post-operational gastrostasis and thus the improved quality of surgical treatment in this group of patients [69, 95, 144].

The traditional radiological and endoscopic methods used for diagnostics of ulcer and its complication do not allow for adequate evaluation of gastric MEF, degree of PDS compensation, effective post-operation monitoring of gastric motor function and objective comparative evaluation of the results of different types of surgical treatment [18, 121, 162].

Until now there is a discussion on the issue of choice of optimal type of organ preserving surgery on duodenum and vagotomy in the patients with complicated ulcer disease, as well as terms of restoration of gastric MEF depending on pre-surgical state of gastric motor function [48, 93, 132, 228].V.G. Rebrov[114],V.A. Stupinet al. [100],N.S. Tropskayaet al. [134], F.Y. Chang [174] justly state that the most informative modern method of study of gastrointestinal functional state is EGEG reflecting direct connection between changes in motor and electric activity of different sections of gastrointestinal tract, however, the method of direct EGED is very limited in clinical practice due to its invasiveness and impossibility to use it for pre-operational diagnostics of motor disorders [42, 87].

Presently more frequently used method is based on the measurement of electric potential from the skin surface of patients extremities, which isPEGEGmethod proposed by V.G. Rebrov [114], but this method of electrophysiological gastrointestinal study is also not widespread until now.

Information on evaluation of disorders of gastric and duodenal MEF in ulcer disease via PEGEG is scarce and reflect only the most basic principles of diagnostics of PDS and post-operational gastrostases [4, 12]. Ambiguous is the evaluation of diagnostic significance of several PEGEG parameters [63], which decreases its diagnostic capabilities. Presence of large amount of inter-related PEGEG parameters requires the use of multivariate statistics methods for its analysis, however we failed to find such works in available literature.

There are no PEGEG-based comparative data on gastric MEF after different organ preserving operations on duodenum during ulcerative disease and va-gotomies, differential diagnostics of pre- and post-surgical disorders of gastric MEF [4, 37, 130].

PEGEGis still not used for determination of indications for vagotomy, as well.

Further study of gastric and duodenal MEF in patients with complicated gastric and duodenal ulcer and the effect of different surgical treatment methods on it will allow for significant improvement in the quality of surgical treatment in this group of patients.

Those actual issues of surgical treatment of complicated ulcer disease lie in the basis of the monograph presented.

We will gladly accept critical notes, proposals and wishes of our readers.

The author would like to thank Nazarov A.B. for his help for their help in the publication of this monograph.

Autors


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